Title of article
2-Aryloxycarbonylthiophene-3-sulfonamides: Highly potent and etA selective endothelin receptor antagonists
Author/Authors
C. B. Raju ، نويسنده , , Chengde Wu، نويسنده , , Rosario Castillo، نويسنده , , Ilya Okun، نويسنده , , Fiona Stavros، نويسنده , , Ming Fai Chan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2093
To page
2098
Abstract
A series of 2-aryloxycarbonylthiophene-3-sulfonamides were synthesized and evaluated to determine their antagonistic activity at the endothelin receptors. N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(3,4-methylenedioxy)phenoxycarbonyl]thiophene-3-sulfonamide was identified as a highly selective, potent (IC50 = 8.3 nM) and low molecular weight nonpeptide antagonist.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788911
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