Author/Authors :
Thomas D. Penning، نويسنده , , Steven W. Kramer، نويسنده , , Len F. Lee، نويسنده , , Paul W. Collins، نويسنده , , Carol M. Koboldt، نويسنده , , Karen Seibert and، نويسنده , , Amy W. Veenhuizen، نويسنده , , Yan Y. Zhang، نويسنده , , Peter C. Isakson، نويسنده ,
Abstract :
A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.
