Author/Authors :
Daniel P. Becker، نويسنده , , Roger Nosal، نويسنده , , Clara I. Villamil، نويسنده , , Gary Gullikson، نويسنده , , Chafiq Moummi، نويسنده , , Dai-Chang Yang، نويسنده , , Daniel L. Flynn، نويسنده ,
Abstract :
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4 agonist in the series, with an EC50 of 217 nM.
