Title of article :
BN 80245: An E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities
Author/Authors :
Olivier Lavergne، نويسنده , , Laurence Lesueur-Ginot، نويسنده , , Francesc Pla Rodas، نويسنده , , Dennis C. H. Bigg، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Abstract :
The crucial E-ring of camptothecin has been modified to afford the homologous β-hydroxylactone derivative BN 80245. This compound, which is more stable than camptothecin, remains a potent inhibitor of both cell growth and topoisomerase I.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
