Novel inhibitors of influenza sialidases related to zanamivir. Heterocyclic replacements of the glycerol sidechain

A series of substituted 4-amino-4H-pyran-2-carboxylic acid 6-triazoles and oxadiazoles are described. The compounds are inhibitors of influenza virus sialidases which, in general, show a similar pattern of activity and selectivity to recently reported 4H-pyran-2-carboxylic acid 6-carboxamides.