Author/Authors :
Anthony D. Pechulis، نويسنده , , Sydney Archer، نويسنده , , Mark P. Wentland، نويسنده , , Ann M. Colasurdo، نويسنده , , Jean M. Bidlack، نويسنده ,
Abstract :
A family of arylacetamide opioid ligands was prepared. Competition binding studies indicate that in each case the (S)-(+) series was two orders of magnitude more potent than the corresponding (R)-(−) series and that the amine (S)-(+)-3 and the acetamide (S)-(+)-4 were selective for the κ opioid binding site. Binding and flow cytometry experiments demonstrated that (S)-(+)-FITC-AA 5 was the enantiomer that bound to the κ opioid receptor.
