Title of article
3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor
Author/Authors
Lawrence A. Reiter، نويسنده , , Lawrence S. Melvin Jr.، نويسنده , , Geraldine L. Crean، نويسنده , , Henry J. Showell، نويسنده , , Kevin Koch، نويسنده , , Michael S. Biggers، نويسنده , , John B. Cheng، نويسنده , , Robbin Breslow، نويسنده , , Maryrose J. Conklyn، نويسنده , , Cathy A. Farrell، نويسنده , , William A. Hada، نويسنده , , Ellen R. Laird، نويسنده , , John J. Martin، نويسنده , , G. Todd Miller، نويسنده , , Joanne S. Pillar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2307
To page
2312
Abstract
The SAR of a series of 7-chromanylacetic acids has been investigated with the aim of identifying potent and selective LTB4 receptor antagonists. We found optimal activity in derivatives with α,α-disubstitution on the acetic acid and a C-4 hydroxy group and a C-3 lipophilic group on the chromane ring. CP-105696 (43), which contains a 4-phenylbenzyl C-3 substituent, was selected for development.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788953
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