Title of article
Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues
Author/Authors
Man-Fai Wong، نويسنده , , Joyce J. Repa، نويسنده , , Margaret Clagett-Dame، نويسنده , , Robert W. Curley Jr، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2313
To page
2318
Abstract
In an effort to synthesize two conformationally restricted retinoids utilizing a cyclopropyl ring as bioisostere for the C9–C10 double bond, we describe the synthetic strategies and retinoid receptor binding affinity of the trans-cyclopropyl analogue and the unexpected epimerization of the cis-cyclopropyl analogue.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788954
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