Title of article :
Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro
Author/Authors :
Yuh-Meei Lin، نويسنده , , David E. Zembower، نويسنده , , Michael T. Flavin، نويسنده , , Ralph M. Schure، نويسنده , , Herbert M. Anderson، نويسنده , , Brent E. Korba، نويسنده , , Fa-Ching Chen، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Abstract :
Robustaflavone, a naturally occurring biflavanoid isolated from the seed kernel extract of Rhus succedanea, was found to be a potent in vitro inhibitor of hepatitis B, with an effective concentration (EC50) of 0.25 μM and an in vitro selectivity index (IC50/EC90) of 153. Further studies suggested that inhibition of HBV DNA polymerase is the mechanism of action.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
