Author/Authors :
Arnaud Genre-Grandpierre، نويسنده , , Daniel R. Talham and Charles Tellier، نويسنده , , Marie-Jeanne Loirat، نويسنده , , Dominique Blanchard، نويسنده , , David R. W. Hodgson، نويسنده , , Florian Hollfelder، نويسنده , , Anthony J. Kirby، نويسنده ,
Abstract :
Rather efficient catalysis of the decomposition of 5-nitro-benzisoxazole to the cyanophenol was observed with antibodies elicited against a cationic hapten structurally unrelated to the benzisoxazole substrate. The rate enhancement by the most active antibody is better than 104 and the reaction is catalyzed by a carboxylate group associated with a hydrophobic binding site.
