Title of article
Oligopresentation of protease inhibitors with β-cyclodextrin as template
Author/Authors
Norbert Schaschke، نويسنده , , Hans-Jürgen Musiol، نويسنده , , Irmgard Assfalg-Machleidt، نويسنده , , Werner Machleidt، نويسنده , , Luis Moroder، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2507
To page
2512
Abstract
Perfacial functionalization of β-cyclodextrin as heptakis-(6-mercapto-6-deoxy)- and heptakis-(6-succinylamido-6-deoxy)-derivative was used to graft the tripeptide aldehyde Leu-Leu-Nle-H to the strongly solubilizing carbohydrate template. Oligopresentation of this inhibitor and thus in loco increase of the concentration was not found to enhance inhibition of cathepsin B and μ-calpain on molar basis if compared to the mono-conjugated form.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788992
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