Title of article
Dihydroisoquinolone RGD mimics. Exploration of the aspartate isostere
Author/Authors
Matthew J. Fisher، نويسنده , , Bruce P. Gunn، نويسنده , , Cathy S. Harms، نويسنده , , Allen D. Kline، نويسنده , , Jeffrey T. Mullaney، نويسنده , , Robert M. Scarborough، نويسنده , , Marshall A. Skelton، نويسنده , , Suzane L. Um، نويسنده , , Barbara G. Utterback، نويسنده , , Joseph A. Jakubowski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2537
To page
2542
Abstract
Disubstituted 3,4-dihydroisoquinolones that contain an ether-linked benzamidine at C6 and a β-substituted aspartate mimic at C2 offer enhanced affinity for GPIIb–IIIa relative to the non-substituted isoquinolone propionate. Alkyl substituents afforded a 10-fold increase in intrinsic activity while aryl substituents yielded a 40-fold improvement.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788998
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