Author/Authors :
Min Chu، نويسنده , , Ronald Mierzwa، نويسنده , , Ellen Barrabee، نويسنده , , Arthur King، نويسنده , , Marc Hallade، نويسنده , , Joseph Terracciano، نويسنده , , Mahesh G. Patel، نويسنده , , Robert Patton Leland، نويسنده , , W. Robert Bishop، نويسنده , , Mohindar S. Puar، نويسنده ,
Abstract :
Novel aromatic dialdehyde, Sch 207278 (1), was isolated from an unidentified fungus as an inhibitor of farnesyl protein transferase (FPTase). The structure of 1 was elucidated by spectroscopic methods. Compound 1 exhibited an IC50 value of 3.5 μM against FPTase and 70 μM against geranylgeranyl protein transferase-1 (GGPTase-1), respectively.
