Title of article
Synthesis and progesterone receptor binding affinity of substituted 1-phenyl-7-benzyl-4,5,6,7-tetrahydro-1 -indazoles
Author/Authors
Peter J. Connolly، نويسنده , , Steven K. Wetter، نويسنده , , Kimberly N. Beers، نويسنده , , Stephanie C. Hamel، نويسنده , , Donna Haynes-Johnson، نويسنده , , Margaret Kiddoe، نويسنده , , Pat Kraft، نويسنده , , Muh Tsann Lai، نويسنده , , Carolyn Campen، نويسنده , , Stephen Palmer، نويسنده , , Audrey Phillips، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2551
To page
2556
Abstract
Research directed toward the discovery of non-steroidal ligands for steroid receptors led to the preparation of a series of substituted 1-phenyl-7-benzyltetrahydroindazole-3-carboxaldehydes. Appropriately substituted 3-formyl analogs (4) were found to bind with high affinity to progesterone receptors and showed agonist activity in human T47D cells but were inactive in several in vivo models for progestational activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789001
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