Author/Authors :
Kozo Shishido، نويسنده , , Shigenori Haruna، نويسنده , , Chisato Yamamura، نويسنده , , Hiromi Iitsuka، نويسنده , , Hisao Nemoto، نويسنده , , Yasuo Shinohara، نويسنده , , Masayuki Shibuya، نويسنده ,
Abstract :
The design and synthesis of enantiomerically enriched hybrid molecules, 1a–c and 2a–c, have been accomplished by employing the lipase-mediated asymmetric acetylation of prochiral diol 9 as the key step. Evaluation of their DNA-cleaving activity has revealed the unnatural type of enantiomer 2a-c to be more potent than 1a-c with natural configuration.
