Author/Authors :
Nakyen Choy، نويسنده , , Ho-il Choi، نويسنده , , Won Hee Jung، نويسنده , , Chung Ryeol Kim، نويسنده , , Heungsik Yoon، نويسنده , , Sung-Chun Kim، نويسنده , , Tae Gyu Lee، نويسنده , , Jong Sung Koh، نويسنده ,
Abstract :
Novel irreversible HIV-1 protease inhibitors containing sulfonamide and sulfone as amide bond isosteres were designed, synthesized, and kinetically characterized. A representative compound 2 displayed rapid, time-dependent inactivation of HIV-1 protease and high potency in cell culture with IC50 of 6.6 nM.
