Author/Authors :
K. H. Gibson، نويسنده , , W Grundy، نويسنده , , A. A. Godfrey، نويسنده , , J. R. Woodburn، نويسنده , , S. E. Ashton، نويسنده , , B. J. Curry، نويسنده , , L Scarlett، نويسنده , , A. J. Barker، نويسنده , , D. S. Brown، نويسنده ,
Abstract :
Investigation of structure-activity relationships of novel quinazolines has identified a 4-(4-iso-quinolylamino)-quinazoline and a 4-(trans-2-phenylcyclopropylamino)-quinazoline as potent inhibitors of EGF-receptor tyrosine kinase in vitro. Further modifications of the latter compound have identified a derivative which shows anti-tumour activity against a tumour xenograft model when dosed orally once per day.
