Toward a transition state analog inhibitor of N-acetylglucosaminyl transferase V

The tumor related enzyme N-acetylglucosaminyltransferase V catalyzes the transfer of GlcNAc to OH-6 of branching Man to give complex oligosaccharide structures. A transition state analog inhibitor of this enzyme was designed and a model compound was synthesized to illustrate the feasibility of the synthetic strategy.