Title of article
Use of CoMFA in validating the conformation used in designing 4-(1H-benzimidazole-2-carbonyl)piperidines with H1/NK1 receptor antagonist activity
Author/Authors
Roy J. Vaz، نويسنده , , George D. Maynard، نويسنده , , Elizabeth M. Kudlacz، نويسنده , , Larry D. Bratton، نويسنده , , John M. Kane، نويسنده , , Scott A. Shatzer، نويسنده , , Robert W. Knippenberg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2825
To page
2830
Abstract
Support for the conformation used in the design of a series of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/tachykinin NK1 receptor antagonist activity has been presented. Comparative Molecular Field Analysis(CoMFA) for both receptor binding affinites of the series as well as overlays with several crystal structures of selective receptor antagonists support the conformation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789053
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