Title of article
Synthesis and structure-activity relationships of novel 3′-Hty-substituted pneumocandins
Author/Authors
Regina M. Black، نويسنده , , James M. Balkovec، نويسنده , , Karl M. Nollstadt، نويسنده , , Sarah Dreikorn، نويسنده , , Kenneth F. Bartizal، نويسنده , , George K. Abruzzo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2879
To page
2884
Abstract
A series of pneumocandin B0 analogs substituted at the 3′ -position of the homotyrosine (Hty) residue have been prepared and evaluated for their inhibition of 1,3-β-( )-glucan synthesis and for their antifungal activity against C. albicans. Cationic analogs displayed enhanced antifungal properties. The phenolic hydroxyl is involved in a critical hydrogen-bond at the binding site of the enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789064
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