Author/Authors :
Catherine Tung-Ling Lee، نويسنده , , Victor Chih-Kuang Lin، نويسنده , , Shun-Xiang Zhang، نويسنده , , Xiao-Kang Zhu، نويسنده , , David VanVliet، نويسنده , , Hong Hu، نويسنده , , Scott A. Beers، نويسنده , , Zhe-Qing Wang، نويسنده , , L. Mark Cosentino، نويسنده , , Susan L. Morris-Natschke، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Abstract :
Podophyllotoxin derivatives containing structural modifications at C-4 and in the methylenedioxy A-ring, lactone D-ring, and phenyl E-ring have been tested for inhibition of HIV replication. The four most promising compounds (6, 7, 8, and 19), with the methylenedioxy A-ring opened and methylated and the 4′-position demethylated, had EC50ʹs less than 0.001 μM and therapeutic indices greater than 120.
