Title of article
3-Benzyloxy-2-phenylpiperidine NK1 antagonists: the influence of alpha methyl substitution
Author/Authors
C. J. Swain، نويسنده , , B. J. Williams، نويسنده , , R. Baker، نويسنده , , M. A. Cascieri، نويسنده , , G. Chicchi، نويسنده , , M. Forrest، نويسنده , , R. Herbert، نويسنده , , L. Keown، نويسنده , , T. Ladduwahetty، نويسنده , , S. Luell، نويسنده , , D. E. MacIntyre، نويسنده , , J. Metzger، نويسنده , , Eugene S. Morton، نويسنده , , A. P. Owens، نويسنده , , S. Sadowski، نويسنده , , A. P. Watt، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
2959
To page
2962
Abstract
In vitro metabolism studies on a series of 3,5-bis(trifluoromethyl)benzyl ethers have identified 3,5-bis(trifluoromethyl)benzoic acid as a significant metabolite possibly arising via oxidation of the benzylic position. A methyl group was introduced in an effort to suppress this route of metabolism. One diastereoisomer displayed an increase in affinity and a marked improvement in duration of action.
Abstract
In vitro metabolism studies on a series of 3,5-bis(trifluoromethyl)benzyl ethers have identified 3,5-bis(trifluoromethyl)benzoic acid as a significant metabolite possibly arising via oxidation at the benzylic position. A methyl group was introduced in an effort to suppress this route of metabolism. One diastereoisomer displayed an increase in affinity and a marked improvement in duration of action
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789080
Link To Document