One step synthesis of orthogonally protected diaminodicarboxylic acids by mixed kolbe electrolysis

Orthogonally protected 2,5-diaminoadipic, 2,6-diaminopimelic, and 2,7-diaminosuberic acid derivatives bearing up to four different protecting groups are prepared in one step by mixed Kolbe electrolysis. The use of 2-[(4-methylphenyl)sulfonyl]ethyl group is crucial for the isolation of the desired orthogonally protected products.