Title of article :
Reversible acylation of elastase by γ-lactam analogues of β-lactam inhibitors
Author/Authors :
Nicholas J. Westwood، نويسنده , , Timothy D. W. Claridge، نويسنده , , Philip N. Edwards، نويسنده , , Andrea G. Prescott and Christopher J. Schofield، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Abstract :
The reaction of a monocyclic γ-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous β-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
