Title of article
Synthesis and membrane permeability of PNA-peptide conjugates
Author/Authors
Carla G. Simmons، نويسنده , , Anne E. Pitts، نويسنده , , Lynn D. Mayfield، نويسنده , , Jerry W. Shay، نويسنده , , David R. Corey، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
3001
To page
3006
Abstract
Chimeric molecules consisting of peptide nucleic acid oligomers (PNAs) and peptides derived from the third helix of the homeodomain of Antennapedia are taken up by mammalian cells in culture. Uptake is independent of orientation and occurs with high efficiency, suggesting that peptide conjugates are a promising strategy for intracellular PNA delivery.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789088
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