Author/Authors :
Charlotte Schou، نويسنده , , Erik R. Ottosen، نويسنده , , Hans J?rgen Petersen، نويسنده , , Fredrik Bj?rkling، نويسنده , , Scilla Latini، نويسنده , , Pernille V. Hjarnaa، نويسنده , , Erik Bramm، نويسنده , , Mona-Lise Binderup، نويسنده ,
Abstract :
4-Pyridyl cyanoguanidines with hydrophobic aromatic side chains showed potent antiproliferative activity in the human breast and lung cancer cell lines MCF-7, NYH and H460. In vivo, treatment with N-(6-chlorophenoxyhexyl)-N′-cyano-N″-4-pyridylguanidine (18, 20 mg/kg/day po.), gave a complete remission of tumours in a model of NYH inoculated nude mice.
