Title of article
7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents
Author/Authors
Hubert Josien، نويسنده , , David Bom، نويسنده , , Dennis P. Curran، نويسنده , , Yu-Huang Zheng، نويسنده , , Ting-Chao Chou، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
3189
To page
3194
Abstract
The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 11-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789125
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