• Title of article

    Chemical inducers of dimerization: The atomic structure of FKBP12-FK1012A-FKBP12

  • Author/Authors

    L. Wayne Schultz، نويسنده , , Jon Clardy، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1998
  • Pages
    6
  • From page
    1
  • To page
    6
  • Abstract
    A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1998
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    789168

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=789168