• Title of article

    Discovery of FR115092 : A novel antinephritic agent

  • Author/Authors

    Takashi Ogino، نويسنده , , Kiyoshi Tsuji، نويسنده , , Takashi Tojo، نويسنده , , Norihiro Igari، نويسنده , , Nobuo Seki، نويسنده , , Yu Sudo، نويسنده , , Toshitaka Manda، نويسنده , , Fusako Nishigaki، نويسنده , , Masaaki Matsuo، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1998
  • Pages
    6
  • From page
    75
  • To page
    80
  • Abstract
    A series of dapsone-related 4-aminophenyl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092, 26) was effective against two nephritis models, namely graft-versus-host disease (GVHD) and autoimmune W/BF1 mice, and showed none of the blood toxicity observed with dapsone.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1998
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    789182

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=789182