Title of article :
Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring
Author/Authors :
Akira Tanaka، نويسنده , , Takeshi Terasawa، نويسنده , , Hiroyuki Hagihara، نويسنده , , Takayoshi Kinoshita، نويسنده , , Yuri Sakuma، نويسنده , , Noriko Ishibe، نويسنده , , Masae Sawada، نويسنده , , Hisashi Takasugi، نويسنده , , Hirokazu Tanaka MD، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
The synthesis, single crystal X-ray structural analysis, and biological activity of FR186054 (2c), a new, potent, orally efficacious inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT), containing a pyrazole ring are described. This compound displayed excellent in vivo efficacy, irrespective of dosing method, indicating superior characteristics compared to other ACAT inhibitors.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
