Author/Authors :
Michele A. Weidner-Wells، نويسنده , , Jason Altom، نويسنده , , Jeffrey Fernandez، نويسنده , , Stephanie A. Fraga-Spano، نويسنده , , Jamese Hilliard، نويسنده , , Kwasi Ohemeng، نويسنده , , John F. Barrett، نويسنده ,
Abstract :
Ellagic acid was found to inhibit E. coli DNA gyrase supercoiling with approximately the same potency as nalidixic acid. Tricyclic analogs of ellagic acid, which vary in the number and position of the hydroxy groups as well as their replacement with halogens, have been synthesized. The biological activity of these analogs is discussed.
