Title of article
Remarkable tethering effect on DNA cleavage of propargylic sulfone conjugates with intercalating moieties
Author/Authors
Wei-Min Dai، نويسنده , , Quan Li، نويسنده , , Kin Chiu Fong، نويسنده , , Chun Wo Chow، نويسنده , , Guo-ling Zhou، نويسنده , , Wataru Hamaguchi، نويسنده , , Sei-ichi Nishimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
169
To page
174
Abstract
A number of novel propargylic sulfone conjugates 3 and 4 with intercalating moieties were synthesized and evaluated for DNA cleavage activity through nucleic base alkylation. A remarkable enhancement in DNA cleaving potency was observed with those conjugates 3 possessing a suitable spacer, a right attachment point at the aromatic ring, and a good intercalator.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789201
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