Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides
Author/Authors :
Robert T. Lum، نويسنده , , Marek G. Nelson، نويسنده , , Alison Joly، نويسنده , , Amy G. Horsma، نويسنده , , Gavin Lee، نويسنده , , Stephanie M. Meyer، نويسنده , , Michael M. Wick، نويسنده , , Steven R. Schow، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
6
From page :
209
To page :
214
Abstract :
Potent inhibitors of the 20S proteasome that contain a novel indanone head group coupled to di and tripeptides are described. These compounds are the first proteasome inhibitors have demonstrated high selectivity for the chymotrypsin-like activity of the 20S proteasome.
