Title of article
Rational design of boropeptide thrombin inhibitors: β,β-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile
Author/Authors
John M. Fevig، نويسنده , , Joseph Buriak Jr.، نويسنده , , Joseph Cacciola، نويسنده , , Richard S. Alexander، نويسنده , , Charles A. Kettner، نويسنده , , Robert M. Knabb، نويسنده , , James R. Pruitt، نويسنده , , Patricia C. Weber، نويسنده , , Ruth R. Wexler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
301
To page
306
Abstract
The potent boropeptide thrombin inhibitor DuP 714 caused side effects in laboratory animals that appear to be related to its ability to inhibit complement factor I, thereby activating the complement cascade. Using X-ray crystal structure information, we have designed compounds that have greater selectivity for thrombin over factor I and that have reduced tendency to produce these side effects.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789230
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