Title of article
Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists
Author/Authors
Paul L. Ornstein، نويسنده , , M. Brian Arnold، نويسنده , , William H. W. Lunn، نويسنده , , Lawrence J. Heinz، نويسنده , , J. David Leander، نويسنده , , David Lodge، نويسنده , , Darryle D. Schoepp، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
389
To page
394
Abstract
We report the synthesis and characterization of compounds that are competitive NMDA receptor antagonists. Significant increases in affinity and potency were obtained by incorporation of a heteroatom into the substructure of the tetrazole-substituted amino acid LY233053.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789247
Link To Document