Author/Authors :
Victor Segarra، نويسنده , , M. Isabel Crespo، نويسنده , , Ferran Pujol، نويسنده , , Jorge Beleta، نويسنده , , Teresa Doménech، نويسنده , , Montserrat Miralpeix، نويسنده , , Jose M. Palacios، نويسنده , , Ana Castro، نويسنده , , Ana Martinez، نويسنده ,
Abstract :
A 4-centre PDE 4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developping PDE 4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured.
