Author/Authors :
Koki Ishibashi، نويسنده , , Katsuyoshi Nakajima، نويسنده , , Yuki Sugioka، نويسنده , , Mitsuo Sugiyama، نويسنده , , Takakazu Hamada، نويسنده , , Hiroyoshi Horikoshi، نويسنده , , Takahide Nishi، نويسنده ,
Abstract :
A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbamoyl group at the 5 or 6 position of the benzofuran ring were synthesized and evaluated for rat and human testosterone 5α-reductase inhibitory activities in vitro. They had inhibitory activities against both enzymes and the 6-carbamoyl derivatives tended to be more potent than the 5-carbamoyl compounds.
