Author/Authors :
Victor Ph. Anufriey، نويسنده , , Vyacheslav L. Novikov، نويسنده , , Oleg B. Maximov، نويسنده , , George B. Elyakov، نويسنده , , Dmitry O. Levitsky، نويسنده , , Alexander V. Lebedev، نويسنده , , Safa M. Sadretdinov، نويسنده , , Alexei V. Shvilkin، نويسنده , , Natalya I. Afonskaya، نويسنده , , Mikhail Ya. Ruda، نويسنده , , Nina M. Cherpachenko، نويسنده ,
Abstract :
A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia-reperfusion and to reduce the infarction zone by 50% without any adverse effect. All compounds exhibit a moderate or small toxicity and are active in low doses.
