Title of article
Diimidazo[1,2-c:4′,5′-e]pyrimidines: Adenosine agonist activity demonstrated by microphysiometry
Author/Authors
David Camp، نويسنده , , Jennifer M. Green، نويسنده , , Sonya M. Kaiser، نويسنده , , Roger W. Moni، نويسنده , , Andrea Townsend-Nicholson، نويسنده , , Peter R. Schofield، نويسنده , , Ronald J. Quinn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
691
To page
694
Abstract
Silicon-based microphysiometry, measuring extracellular acidification rate of cells in culture, demonstrated that a series of diimidazo[1,2-c:4′,5′-e]pyrimidines were agonists at the human adenosine A1 receptor. 5-amino-7,8-dihydro-3-ribofuranose-8-(R)-(phenyl)-3H-diimidazo[1,2-c:4′,5′-e]pyrimidine (2a) had an EC50 of 100 μM and reached 90% of the Emax produced by R-PIA.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789305
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