Diimidazo[1,2-c:4′,5′-e]pyrimidines: N6-N1 conformationally restricted adenosines

Tethering the N6-substituents of N6-substituted adenosines to N1 has resulted in a series of conformationally restricted adenosine analogues. The resultant diimidazo[1,2-c:4′,5′-e]pyrimidines were shown to be adenosine A1 selective.