Title of article
New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone
Author/Authors
James P. Edwards، نويسنده , , Sarah J. West، نويسنده , , Charlotte L. F. Pooley، نويسنده , , Keith B. Marschke، نويسنده , , Luc J. Farmer، نويسنده , , Todd K. Jones، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
745
To page
750
Abstract
A series of 2(1H)-pyrrolidino[3,2-g]quinolinones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound. 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone, displayed moderate interaction with hAR, but more substituted analogues, particularly 6,7-disubstituted compounds, were potent hAR agonists in vitro.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789316
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