Author/Authors :
Mona Patel، نويسنده , , Lee T. Bacheler، نويسنده , , Marlene M. Rayner، نويسنده , , Beverly C. Cordova، نويسنده , , Ronald M. Klabe، نويسنده , , Susan Erickson-Viitanen، نويسنده , , Steven P. Seitz، نويسنده ,
Abstract :
Two series of cyclic ureas modified at the P1/P1′ residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity. Compounds 8b, 10 (3- and 4-pyridylmethyl analogs) and 6b (4-methoxy analog) showed significant improvement in antiviral activity relative to lead compounds DMP323 and DMP 450.
