Author/Authors :
Andreas von Sprecher، نويسنده , , Marc Gerspacher، نويسنده , , Andreas Beck، نويسنده , , Sabine Kimmel، نويسنده , , Hansruedi Wiestner، نويسنده , , Gary P. Anderson، نويسنده , , Ulrich Niederhauser، نويسنده , , Natarajan Subramanian، نويسنده , , Michael A. Bray، نويسنده ,
Abstract :
The two geminal ethyl groups in the succinic acid moiety of CGP57698 (4-[3-(7-fluoro-2-quinolinyl-methoxy)phenyl-amino]-2,2-diethyl-4-oxo-butanoic acid) are responsible for the high in vitro and in vivo potency of this peptidoleukotriene antagonist of the quinoline type. The synthesis and structure activity relationships of CGP57698 and its analogs are described.
