Structure based design: Novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors
Author/Authors :
Arun K. Ghosh، نويسنده , , K. Krishnan، نويسنده , , D. Eric Walters، نويسنده , , Wonhwa Cho، نويسنده , , Hanna Cho، نويسنده , , Yumee Koo، نويسنده , , Jose Trevino، نويسنده , , Louis Holland، نويسنده , , Jim Buthod، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
4
From page :
979
To page :
982
Abstract :
A series of novel spirocyclic ethers were designed to function as nonpeptidal P2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors.
