Title of article
Design and synthesis of a new type of non steroidal human aromatase inhibitors
Author/Authors
P. Sonnet، نويسنده , , J. Guillon، نويسنده , , C. Enguehard، نويسنده , , P. Dallemagne، نويسنده , , R. Bureau، نويسنده , , S. Rault، نويسنده , , P. Auvray، نويسنده , , S. Moslemi، نويسنده , , P. Sourdaine، نويسنده , , S. Galopin and، نويسنده , , G. -E. Séralini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
1041
To page
1044
Abstract
The structure-activity relationship study of one of recently described aromatase inhibitors, compound 1 (MR20814), allowed us to design some related derivatives as potential new inhibitors. Among those we synthesized, chlorophenylpyridylmethylenetetrahydroindolizinone 5 (MR20492) exhibited in vitro a ten-fold higher inhibition of the enzyme (IC50 = 0.2±0.0 μM and Ki = 10.3±3.3 nM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789372
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