Title of article
A novel super-potent neurokinin A receptor antagonist containing dehydroalanine
Author/Authors
Angela Lombardi، نويسنده , , Bruno DʹAgostino، نويسنده , , Flavia Nastri، نويسنده , , Luca D. DʹAndrea، نويسنده , , Amelia Filippelli، نويسنده , , Maddalena Falciani، نويسنده , , Francesco Rossi، نويسنده , , Vincenzo Pavone، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
1153
To page
1156
Abstract
We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity. Its pharmacological properties as a neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and were compared to those of Neuronorm and MEN10627.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789394
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