Author/Authors :
Angela Lombardi، نويسنده , , Bruno DʹAgostino، نويسنده , , Flavia Nastri، نويسنده , , Luca D. DʹAndrea، نويسنده , , Amelia Filippelli، نويسنده , , Maddalena Falciani، نويسنده , , Francesco Rossi، نويسنده , , Vincenzo Pavone، نويسنده ,
Abstract :
We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity. Its pharmacological properties as a neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and were compared to those of Neuronorm and MEN10627.
