Title of article
Synthesis and anti-inflammatory activity of chalcone derivatives
Author/Authors
Felipe Herencia، نويسنده , , M. Luisa Ferr?ndiz، نويسنده , , Amalia Ubeda، نويسنده , , JoséN. Dom?nguez، نويسنده , , Jaime E. Charris، نويسنده , , Gricela M. Lobo، نويسنده , , M. José Alcaraz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1169
To page
1174
Abstract
Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide. Only four compounds (4–7) inhibited cyclo-oxygenase-2-activity. The majority of these samples showed anti-inflammatory effects in the mouse air pouch model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789397
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