Author/Authors :
Felipe Herencia، نويسنده , , M. Luisa Ferr?ndiz، نويسنده , , Amalia Ubeda، نويسنده , , JoséN. Dom?nguez، نويسنده , , Jaime E. Charris، نويسنده , , Gricela M. Lobo، نويسنده , , M. José Alcaraz، نويسنده ,
Abstract :
Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide. Only four compounds (4–7) inhibited cyclo-oxygenase-2-activity. The majority of these samples showed anti-inflammatory effects in the mouse air pouch model.
