Title of article :
A depsipeptide fungal metabolite inhibitor of cholesteryl ester transfer protein
Author/Authors :
Vinod R. Hegde، نويسنده , , Ping Dai، نويسنده , , Mahesh Patel، نويسنده , , Pradip R. Das، نويسنده , , Suke Wang، نويسنده , , Mohindar S. Puar، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
The organic extract of the fermentation broth of a fungus was found to contain a depsipeptide SCH 58149 (1), containing three amino acids and a β-hydroxy acid, by spectroscopic studies. The amino acids were phenyl alanine, alanine and leucine and the β-hydroxy acid is 3-hydroxy-4-methyl octanoic acid. SCH 58149 exhibited weak activity against cholesterol ester transfer protein (CETP) with an IC50 of 50 μM.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
