Author/Authors :
Jianzhong Chen ، نويسنده , , LiHong Hu، نويسنده , , Hualiang Jiang and Helmut Grubmüller، نويسنده , , JianDe Gu، نويسنده , , WeiLiang Zhu، نويسنده , , ZhongLiang Chen، نويسنده , , KaiXian Chen، نويسنده , , RuYun Ji، نويسنده ,
Abstract :
Comparative molecular field analysis (CoMFA), a three-dimensional quantitative structure-activity relationship (3D-QSAR) paradigm was used to study the correlation between the physicochemical properties and the in vitro bioactivities of ginkgolide analogues. The correlation derived from CoMFA analysis has a good predictive capability. Based on the result of CoMFA analysis, we designed some compounds. Pharmacological assay indicated that three of these new designed compounds are 2 and 4 times more potent than that of ginkgolides.
