Title of article
A 3D-QSAR study on ginkgolides and their analogues with comparative molecular field analysis
Author/Authors
Jianzhong Chen ، نويسنده , , LiHong Hu، نويسنده , , Hualiang Jiang and Helmut Grubmüller، نويسنده , , JianDe Gu، نويسنده , , WeiLiang Zhu، نويسنده , , ZhongLiang Chen، نويسنده , , KaiXian Chen، نويسنده , , RuYun Ji، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1291
To page
1296
Abstract
Comparative molecular field analysis (CoMFA), a three-dimensional quantitative structure-activity relationship (3D-QSAR) paradigm was used to study the correlation between the physicochemical properties and the in vitro bioactivities of ginkgolide analogues. The correlation derived from CoMFA analysis has a good predictive capability. Based on the result of CoMFA analysis, we designed some compounds. Pharmacological assay indicated that three of these new designed compounds are 2 and 4 times more potent than that of ginkgolides.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789420
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