Author/Authors :
Yousuke Katsura، نويسنده , , Shigetaka Nishino، نويسنده , , Tetsuo Tomishi، نويسنده , , Kazuo Sakane، نويسنده , , Yoshimi Matsumoto، نويسنده , , Hirohumi Ishikawa، نويسنده , , Hisashi Takasugi، نويسنده ,
Abstract :
SAR for antimicrobial activity against H. pylori was investigated in a new series of 2-alkylguanidino-4-furylthiazoles. Of the compounds obtained, cyclohexylmethyl and ethoxyethyl derivatives were identified as a novel class of anti-H. pylori agents which possessed potent and selective antimicrobial activity against H. pylori. These compounds also showed gastric antisecretory activity.
